Important Treatment Considerations

Renvela® (sevelamer carbonate) is used to control phosphorus levels in patients with chronic kidney disease (CKD) on dialysis · Do not use Renvela if you have a history of bowel obstruction · Talk to your doctor if you have had digestive tract surgery or other digestive disorders, including severe constipation · Uncommon cases of bowel obstruction and perforation have been reported · Your doctor should monitor bicarbonate and chloride blood levels · Vitamins D, E, K (clotting factors), and folic acid blood levels should also be monitored by your doctor · The most frequently occurring side effects observed with sevelamer carbonate tablets were nausea and vomiting · Side effects with sevelamer carbonate powder taken three times a day were similar to those reported for sevelamer carbonate tablets · The most common side effects with sevelamer hydrochloride, which contains the same active ingredient as sevelamer carbonate, included: vomiting, nausea, diarrhea, dyspepsia, abdominal pain, flatulence, and constipation · Cases of fecal impaction and, less commonly, ileus, bowel obstruction, and bowel perforation have been reported · Take Renvela with meals and adhere to your prescribed diet · Talk to your doctor when taking Renvela with other medications · Promptly contact your doctor if you experience severe abdominal pain, new or worsening constipation, or other severe intestinal symptoms while on Renvela

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